Publications
Information about journal articles, updated at 20-07-2025, from platform CIÊNCIAVITAE.
Early life behavioral deficits and microglia remodeling in the mesocorticolimbic system precede the emergence of Schizophrenia-like symptoms
Rodrigues-Neves, Ana C.; Monteiro, Jéssica; Coimbra, Bárbara; Gaspar, Rita; Domingues, Verónica; Soares-Cunha, Carina; Patrício, Patrícia; et al, Brain, Behavior, and Immunity. 2025. https://doi.org/10.1016/j.bbi.2025.06.009 . 10.1016/j.bbi.2025.06.009 . published Brain, Behavior, and Immunity
Early-life IL-4 administration induces long-term changes in microglia in the cerebellum and prefrontal cortex
Ferreira, Pedro A.; Lebre, Carolina; Costa, Jéssica; Amaral, Francisca; Ferreira, Rosário; Martinho, Filipe; Paiva, Vítor H.; et al, Journal of Neurochemistry. 1. 169. 2024. https://doi.org/10.1111/jnc.16266 . 10.1111/jnc.16266 . Journal of Neurochemistry
MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress
Rodrigues, Beatriz; Leitão, Ricardo A.; Santos, Mónica; Trofimov, Alexander; Silva, Mariline; Inácio, Ângela S.; Abreu, Mónica; et al, Molecular Psychiatry. 1034 - 1046. 3. 30. 2024. https://doi.org/10.1038/s41380-024-02715-1 . 10.1038/s41380-024-02715-1 . Molecular Psychiatry
IL-4 shapes microglia-dependent pruning of the cerebellum during postnatal development
Guedes, Joana R.; Ferreira, Pedro A.; Costa, Jéssica; Laranjo, Mariana; Pinto, Maria J.; Reis, Tiago; Cardoso, Ana Maria; et al, Neuron. 3435 - 3449.e8. 21. 111. 2023. http://dx.doi.org/10.1016/j.neuron.2023.09.031 . 10.1016/j.neuron.2023.09.031 . Neuron
A Novel Genetic Variant in MBD5 Associated with Severe Epilepsy and Intellectual Disability: Potential Implications on Neural Primary Cilia
Martins, Mariana; Oliveira, Ana Rafaela; Martins, Solange; Vieira, José Pedro; Perdigão, Pedro; Fernandes, Ana Rita; de Almeida, Luís Pereira; et al, International Journal of Molecular Sciences. 16. 24. 2023. http://dx.doi.org/10.3390/ijms241612603 . 10.3390/ijms241612603 . published International Journal of Molecular Sciences
ZIKV Strains Elicit Different Inflammatory and Anti-Viral Responses in Microglia Cells
Oliveira, Fernanda Bellaniza Caminha de; Freire, Vanessa Paola Alves Sampaio de Sá; Coelho, Sharton Vinicius Antunes; Meuren, Lana Monteiro; Palmeira, Julys da Fonseca; Cardoso, Ana Luísa; Neves, Francisco de Assis Rocha; et al, Viruses. 6. 15. 2023. http://dx.doi.org/10.3390/v15061250 . 10.3390/v15061250 . published Viruses
Peripheral inflammatory markers during an acute bacterial infection in older patients with and without cognitive dysfunction: A case control study
Regueira, Patrícia; Silva, Ana Rita; Cardoso, Ana Luísa; Cardoso, Ana Maria; Baldeiras, Inês; Santana, Isabel; Cerejeira, Joaquim, Brain, Behavior, & Immunity - Health. 25. 2022. http://dx.doi.org/10.1016/j.bbih.2022.100503 . 10.1016/j.bbih.2022.100503 . published Brain, Behavior, & Immunity - Health
In vivo molecular imaging of the neuroinflammatory response to peripheral acute bacterial infection in older patients with cognitive dysfunction: A cross-sectional controlled study
Silva, Ana Rita; Regueira, Patricia; Peres, André; Cardoso, Ana Luísa; Baldeiras, Inês; Santana, Isabel; Cerejeira, Joaquim, Frontiers in Aging Neuroscience. 14. 2022. http://dx.doi.org/10.3389/fnagi.2022.984178 . 10.3389/fnagi.2022.984178 . published Frontiers in Aging Neuroscience
Microglia-dependent remodeling of neuronal circuits
Guedes, Joana R.; Ferreira, Pedro A.; Costa, Jéssica M.; Cardoso, Ana L.; Peça, João, Journal of Neurochemistry. 74 - 93. 2. 163. 2022. http://dx.doi.org/10.1111/jnc.15689 . 10.1111/jnc.15689 . published Journal of Neurochemistry
Generation and Characterization of Novel iPSC Lines from a Portuguese Family Bearing Heterozygous and Homozygous GRN Mutations
Oliveira, Ana Rafaela; Martins, Solange; Cammarata, Giuseppe; Martins, Mariana; Cardoso, Ana Maria; Almeida, Maria Rosário; do Carmo Macário, Maria; et al, Biomedicines. 8. 10. 2022. http://dx.doi.org/10.3390/biomedicines10081905 . 10.3390/biomedicines10081905 . published Biomedicines
Cognitive trajectories following acute infection in older patients with and without cognitive impairment: an one-year follow-up study
Costa Silva, Ana Rita; Regueira, Patrícia; Cardoso, Ana; Baldeiras, Ines; Santana, Isabel; Cerejeira, Joaquim, Frontiers in Psychiatry. 2022. in press Frontiers in Psychiatry
Regeneration of pulp-dentin complex using human stem cells of the apical papilla: in vivo interaction with two bioactive materials
Sequeira, Diana; Oliveira, Ana Rafaela; Seabra, Catarina M.; Palma, Paulo; Peça, João; Cardoso, Ana; Santos, João Miguel, Clinical Oral Investigations. 2021. accepted Clinical Oral Investigations
The old guard: Age-related changes in microglia and their consequences
Jéssica Costa; Solange Martins; Pedro A. Ferreira; Ana M.S. Cardoso; Joana R. Guedes; João Peça; Ana L. Cardoso, Mechanisms of Ageing and Development. 111512 - 111512. 197. 2021. https://doi.org/10.1016/j.mad.2021.111512 . 10.1016/j.mad.2021.111512 . Mechanisms of Ageing and Development
Cognitive Trajectories Following Acute Infection in Older Patients With and Without Cognitive Impairment: An 1-Year Follow-Up Study
Silva, Ana Rita; Regueira, Patrícia; Cardoso, Ana Luísa; Baldeiras, Inês; Santana, Isabel; Cerejeira, Joaquim; Costa Silva, Ana Rita; et al, Frontiers in Psychiatry. 12. 2021. http://dx.doi.org/10.3389/fpsyt.2021.754489 . 10.3389/fpsyt.2021.754489 . in press Frontiers in Psychiatry
Estimates of Geriatric Delirium Frequency in Noncardiac Surgeries and Its Evaluation Across the Years: A Systematic Review and Meta-analysis
Silva, Ana Rita; Regueira, Patrícia; Albuquerque, Elisabete; Baldeiras, Inês; Cardoso, Ana Luísa; Santana, Isabel; Cerejeira, Joaquim, Journal of the American Medical Directors Association. 2020. http://dx.doi.org/10.1016/j.jamda.2020.08.017 . 10.1016/j.jamda.2020.08.017 . published Journal of the American Medical Directors Association
Social subordination induced by early life adversity rewires inhibitory control of the prefrontal cortex via enhanced Npy1r signaling
Franco, Lara O.; Carvalho, Mário J.; Costa, Jéssica; Ferreira, Pedro A.; Guedes, Joana R.; Sousa, Renato; Cardoso, Ana L.; Peça, João, Neuropsychopharmacology. 1438 - 1447. 9. 45. 2020. http://dx.doi.org/10.1038/s41386-020-0727-7 . 10.1038/s41386-020-0727-7 . published Neuropsychopharmacology
miRNA-31 Improves Cognition and Abolishes Amyloid-ß Pathology by Targeting APP and BACE1 in an Animal Model of Alzheimer’s Disease
Barros-Viegas, Ana Teresa; Guedes, Joana; Cardoso, Ana Maria; Pereira de Almeida, Luís; Resende de Oliveira, Catarina; Pedro de Magalhães, João; Peça, João; Cardoso, Ana Luísa, Molecular Therapy - Nucleic Acids. 1219 - 1236. 19. 2020. http://dx.doi.org/10.1016/j.omtn.2020.01.010 . 10.1016/j.omtn.2020.01.010 . published Molecular Therapy - Nucleic Acids
Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice
Edfawy, Mohamed; Guedes, Joana R.; Pereira, Marta I.; Laranjo, Mariana; Carvalho, Mário J.; Cardoso, Ana Luísa; Peça, João, Nature Communications. 1. 10. 2019. http://dx.doi.org/10.1038/s41467-019-09382-9 . 10.1038/s41467-019-09382-9 . Nature Communications
Multimodal highly fluorescent-magnetic nanoplatform to target transferrin receptors in cancer cells
Cabral Filho, P.E.; Cabrera, M.P.; Cardoso, A.L.C.; Santana, O.A.; Geraldes, C.F.G.C.; Santos, B.S.; Pedroso de Lima, M.C.; Pereira, G.A.L.; Fontes, A., Biochimica et Biophysica Acta - General Subjects. 2788 - 2796. 12. 1862. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85052949793&partnerID=MN8TOARS . 10.1016/j.bbagen.2018.08.014 . Biochimica et Biophysica Acta - General Subjects
Effects of a New Bioceramic Material on Human Apical Papilla Cells
Sequeira, Diana; Seabra, Catarina; Palma, Paulo; Cardoso, Ana; Peça, João; Santos, João, Journal of Functional Biomaterials. 4. 9. 2018. http://dx.doi.org/10.3390/jfb9040074 . 10.3390/jfb9040074 . Journal of Functional Biomaterials
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases
Cardoso, Ana Luisa; Fernandes, Adelaide; Aguilar-Pimentel, Juan Antonio; de Angelis, Martin Hrabe; Guedes, Joana Ribeiro; Brito, Maria Alexandra; Ortolano, Saida; et al, Ageing Research Reviews. 214 - 277. 47. 2018. http://dx.doi.org/10.1016/j.arr.2018.07.004 IF=8.973 . 10.1016/j.arr.2018.07.004 . Ageing Research Reviews
Roles of Microglial and Monocyte Chemokines and Their Receptors in Regulating Alzheimer's Disease-Associated Amyloid-ß and Tau Pathologies
Guedes, Joana R.; Lao, Taotao; Cardoso, Ana L.; El Khoury, Joseph, Frontiers in Neurology. 9. 2018. http://dx.doi.org/10.3389/fneur.2018.00549 IF=3.508 . 10.3389/fneur.2018.00549 . Frontiers in Neurology
miRNAs: New biomarkers and therapeutic targets in dementia
Viegas, A.T.B.; Guedes, J.R.; Oliveira, A.R.; Cardoso, A.M.S.; Cardoso, A.L.C., Current Pharmaceutical Design. 669 - 692. 5. 23. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017530528&partnerID=MN8TOARS . 10.2174/1381612823666170111094702 . Current Pharmaceutical Design
High-throughput screening uncovers miRNAs enhancing glioblastoma cell susceptibility to tyrosine kinase inhibitors
Cunha, P.P.; Costa, P.M.; Morais, C.M.; Lopes, I.R.; Cardoso, A.M.; Cardoso, A.L.; Mano, M.; Jurado, A.S.; Pedroso De Lima, M.C.P., Human Molecular Genetics. 4375 - 4387. 22. 26. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034256071&partnerID=MN8TOARS . 10.1093/hmg/ddx323 . Human Molecular Genetics
MicroRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer's disease
Guedes, Joana R.; Santana, Isabel; Cunha, Catarina; Duro, Diana; Almeida, Maria R.; Cardoso, Ana M.; de Lima, Maria C. Pedroso; Cardoso, Ana L., Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 7 - 17. 3. 2016. http://dx.doi.org/10.1016/j.dadm.2015.11.004 . 10.1016/j.dadm.2015.11.004 . Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Role of microRNAs in the regulation of innate immune cells under neuroinflammatory conditions
Cardoso, Ana L; Guedes, Joana R; de Lima, Maria C Pedroso, Current Opinion in Pharmacology. 1 - 9. 26. 2016. http://dx.doi.org/10.1016/j.coph.2015.09.001 IF=5.563 . 10.1016/j.coph.2015.09.001 . Current Opinion in Pharmacology
Frailty in mouse ageing: A conceptual approach
von Zglinicki, Thomas; Varela-Nieto, Isabel; Brites, Dora; Karagianni, Niki; Ortolano, Saida; Georgopoulos, Spiros; Cardoso, Ana Luisa; et al, Mechanisms of Ageing and Development. 34 - 40. 160. 2016. http://dx.doi.org/10.1016/j.mad.2016.07.004 IF=3.087 . 10.1016/j.mad.2016.07.004 . Mechanisms of Ageing and Development
CdTe quantum dots as fluorescent probes to study transferrin receptors in glioblastoma cells
Cabral Filho, P.E.; Cardoso, A.L.C.; Pereira, M.I.A.; Ramos, A.P.M.; Hallwas, F.; Castro, M.M.C.A.; Geraldes, C.F.G.C.; et al, Biochimica et Biophysica Acta - General Subjects. 28 - 35. 1. 1860. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946430431&partnerID=MN8TOARS . 10.1016/j.bbagen.2015.09.021 . Biochimica et Biophysica Acta - General Subjects
Gemini Surfactants Mediate Efficient Mitochondrial Gene Delivery and Expression
Cardoso, A.M.; Morais, C.M.; Cruz, A.R.; Cardoso, A.L.; Silva, S.G.; Do Vale, M.L.; Marques, E.F.; Pedroso De Lima, M.C.; Jurado, A.S., Molecular Pharmaceutics. 716 - 730. 3. 12. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924023696&partnerID=MN8TOARS . 10.1021/mp5005349 . Molecular Pharmaceutics
MicroRNAs in Glioblastoma: Role in Pathogenesis and Opportunities for Targeted Therapies
Costa, Pedro; Cardoso, Ana; Mano, Miguel; Lima, Maria, CNS & Neurological Disorders - Drug Targets. 222 - 238. 2. 14. 2015. http://dx.doi.org/10.2174/1871527314666150116123610 IF=2.188 . 10.2174/1871527314666150116123610 . CNS & Neurological Disorders - Drug Targets
MicroRNAs in glioblastoma: Role in pathogenesis and opportunities for targeted therapies
Costa, P.M.; Cardoso, A.L.; Mano, M.; de Lima, M.C.P., CNS and Neurological Disorders - Drug Targets. 222 - 238. 2. 14. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930907378&partnerID=MN8TOARS . CNS and Neurological Disorders - Drug Targets
MiRNA-21 silencing mediated by tumor-targeted nanoparticles combined with sunitinib: A new multimodal gene therapy approach for glioblastoma
Costa, P.M.; Cardoso, A.L.; Custódia, C.; Cunha, P.; Pereira De Almeida, L.; Pedroso De Lima, M.C., Journal of Controlled Release. 31 - 39. 207. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926665383&partnerID=MN8TOARS . 10.1016/j.jconrel.2015.04.002 . Journal of Controlled Release
Early miR-155 upregulation contributes to neuroinflammation in Alzheimer's disease triple transgenic mouse model
Guedes, J.R.; Custódia, C.M.; Silva, R.J.; de Almeida, L.P.; de Lima, M.C.P.; Cardoso, A.L., Human Molecular Genetics. 6286 - 6301. 23. 23. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926341070&partnerID=MN8TOARS . 10.1093/hmg/ddu348 . Human Molecular Genetics
Application of thermoresponsive PNIPAAM-b-PAMPTMA diblock copolymers in siRNA delivery
Cardoso, A.M.; Calejo, M.T.; Morais, C.M.; Cardoso, A.L.; Cruz, R.; Zhu, K.; Pedroso De Lima, M.C.; Jurado, A.S.; Nyström, B., Molecular Pharmaceutics. 819 - 827. 3. 11. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901742907&partnerID=MN8TOARS . 10.1021/mp400510a . Molecular Pharmaceutics
Tumor-targeted Chlorotoxin-coupled Nanoparticles for Nucleic Acid Delivery to Glioblastoma Cells: A Promising System for Glioblastoma Treatment
Costa, Pedro M; Cardoso, Ana L; Mendonça, Liliana S; Serani, Angelo; Custódia, Carlos; Conceição, Mariana; Simões, Sérgio; et al, Molecular Therapy - Nucleic Acids. 2. 2013. http://dx.doi.org/10.1038/mtna.2013.30 IF=6.425 . 10.1038/mtna.2013.30 . Molecular Therapy - Nucleic Acids
Involvement of MicroRNA in Microglia-Mediated Immune Response
Guedes, J.; Cardoso, A. L. C.; Pedroso de Lima, M. C., Clinical and Developmental Immunology. 1 - 11. 2013. 2013. http://dx.doi.org/10.1155/2013/186872 IF=2.934 . 10.1155/2013/186872 . Clinical and Developmental Immunology
Temperature-responsive cationic block copolymers as nanocarriers for gene delivery
Calejo, Maria Teresa; Cardoso, Ana Maria S.; Kjøniksen, Anna-Lena; Zhu, Kaizheng; Morais, Catarina M.; Sande, Sverre Arne; Cardoso, Ana Luísa; et al, International Journal of Pharmaceutics. 105 - 114. 1. 448. 2013. http://dx.doi.org/10.1016/j.ijpharm.2013.03.028 IF=3.785 . 10.1016/j.ijpharm.2013.03.028 . International Journal of Pharmaceutics
Cell-penetrating peptides as nucleic acid delivery systems: From biophysics to biological applications
Trabulo, S.; Cardoso, A.L.; Cardoso, A.M.S.; Morais, C.M.; Jurado, A.S.; Pedroso de Lima, M.C., Current Pharmaceutical Design. 2895 - 2923. 16. 19. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878655380&partnerID=MN8TOARS . 10.2174/1381612811319160006 . Current Pharmaceutical Design
MicroRNA-21 silencing enhances the cytotoxic effect of the antiangiogenic drug sunitinib in glioblastoma
Costa, P.M.; Cardoso, A.L.; Nóbrega, C.; Pereira de almeida, L.F.; Bruce, J.N.; Canoll, P.; Pedroso de Lima, M.C., Human Molecular Genetics. 904 - 918. 5. 22. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873438180&partnerID=MN8TOARS . 10.1093/hmg/dds496 . Human Molecular Genetics
Comparison of the efficiency of complexes based on S4<inf>13</inf>-PV cell-penetrating peptides in plasmid DNA and siRNA delivery
Cardoso, A.M.; Trabulo, S.; Cardoso, A.L.; Maia, S.; Gomes, P.; Jurado, A.S.; Pedroso De Lima, M.C., Molecular Pharmaceutics. 2653 - 2666. 7. 10. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879735661&partnerID=MN8TOARS . 10.1021/mp400078h . Molecular Pharmaceutics
S4(13)-PV cell-penetrating peptide induces physical and morphological changes in membrane-mimetic lipid systems and cell membranes: Implications for cell internalization
Cardoso, Ana M.S.; Trabulo, Sara; Cardoso, Ana L.; Lorents, Annely; Morais, Catarina M.; Gomes, Paula; Nunes, Cláudia; et al, Biochimica et Biophysica Acta (BBA) - Biomembranes. 877 - 888. 3. 1818. 2012. http://dx.doi.org/10.1016/j.bbamem.2011.12.022 IF=3.389 . 10.1016/j.bbamem.2011.12.022 . Biochimica et Biophysica Acta (BBA) - Biomembranes
PDGF-B-mediated downregulation of miR-21: New insights into PDGF signaling in glioblastoma
Costa, P.M.; Cardoso, A.L.; Pereira de almeida, L.F.; Bruce, J.N.; Canoll, P.; Pedroso de lima, M.C., Human Molecular Genetics. 5118 - 5130. 23. 21. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869025536&partnerID=MN8TOARS . 10.1093/hmg/dds358 . Human Molecular Genetics
miR-155 modulates microglia-mediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production
Cardoso, Ana L.; Guedes, Joana R.; Pereira de Almeida, Luís; Pedroso de Lima, Maria C., Immunology. 73 - 88. 1. 135. 2011. http://dx.doi.org/10.1111/j.1365-2567.2011.03514.x IF=3.705 . 10.1111/j.1365-2567.2011.03514.x . Immunology
Survivin silencing as a promising strategy to enhance the sensitivity of cancer cells to chemotherapeutic agents
Trabulo, S.; Cardoso, A.M.; Santos-Ferreira, T.; Cardoso, A.L.; Simões, S.; Pedroso De Lima, M.C., Molecular Pharmaceutics. 1120 - 1131. 4. 8. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79961082146&partnerID=MN8TOARS . 10.1021/mp100426e . Molecular Pharmaceutics
Cell-Penetrating Peptides—Mechanisms of Cellular Uptake and Generation of Delivery Systems
Trabulo, Sara; Cardoso, Ana Luísa; Mano, Miguel; De Lima, Maria C. Pedroso, Pharmaceuticals. 961 - 993. 4. 3. 2010. http://dx.doi.org/10.3390/ph3040961 . 10.3390/ph3040961 . Pharmaceuticals
Tf-lipoplex-mediated c-Jun silencing improves neuronal survival following excitotoxic damage in vivo
Cardoso, A.L.C.; Costa, P.; de Almeida, L.P.; Simões, S.; Plesnila, N.; Culmsee, C.; Wagner, E.; Pedroso de Lima, M.C., Journal of Controlled Release. 392 - 403. 3. 142. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77349098528&partnerID=MN8TOARS . 10.1016/j.jconrel.2009.11.004 . Journal of Controlled Release
Tf-lipoplexes for neuronal siRNA delivery: A promising system to mediate gene silencing in the CNS
Cardoso, A.L.C.; Simões, S.; de Almeida, L.P.; Plesnila, N.; Pedroso de Lima, M.C.; Wagner, E.; Culmsee, C., Journal of Controlled Release. 113 - 123. 2. 132. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-56349102126&partnerID=MN8TOARS . 10.1016/j.jconrel.2008.08.014 . Journal of Controlled Release
S4<inf>13</inf>-PV cell penetrating peptide and cationic liposomes act synergistically to mediate intracellular delivery of plasmid DNA
Trabulo, S.; Mano, M.; Faneca, H.; Cardoso, A.L.; Duarte, S.; Henriques, A.; Paiva, A.; et al, Journal of Gene Medicine. 1210 - 1222. 11. 10. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149190435&partnerID=MN8TOARS . 10.1002/jgm.1247 . Journal of Gene Medicine
siRNA delivery by a transferrin-associated lipid-based vector: A non-viral strategy to mediate gene silencing
Cardoso, A.L.C.; Simões, S.; de Almeida, L.P.; Pelisek, J.; Culmsee, C.; Wagner, E.; Pedroso de Lima, M.C., Journal of Gene Medicine. 170 - 183. 3. 9. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34047102911&partnerID=MN8TOARS . 10.1002/jgm.1006 . Journal of Gene Medicine
Liposomal and Viral Vectors for Gene Therapy of the Central Nervous System
P. de Lima, M.; Girao da Cruz, M.; C. Cardoso, A.; Simoes, S.; de Almeida, L., Current Drug Target -CNS & Neurological Disorders. 453 - 465. 4. 4. 2005. http://dx.doi.org/10.2174/1568007054546144 IF=3.236 . 10.2174/1568007054546144 . Current Drug Target -CNS & Neurological Disorders
Tf-lipoplex-mediated NGF gene transfer to the CNS: neuronal protection and recovery in an excitotoxic model of brain injury
Teresa Girão da Cruz, M; Cardoso, A L C; de Almeida, L P; Simões, S; Pedroso de Lima, M C, Gene Therapy. 1242 - 1252. 16. 12. 2005. http://dx.doi.org/10.1038/sj.gt.3302516 IF=5.18 . 10.1038/sj.gt.3302516 . Gene Therapy
5 51 out of 51 Publications
All projects
Information of exclusive responsibility of the researcher 20-07-2025 , from platform CIÊNCIAVITAE.
2024/06/01 - 2025/01/31
Empathic Spaces - Immersive VR architectural installation for mental health awareness.
168
Researcher
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia
Funders: Universidade de Coimbra
2023/03/01 - 2026/02/28
Th2brain: Effects of Th2-related immunity in the postnatal maturation of brain circuits
2022.02604.PTDC
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2022/03 - 2023/03
BrainCils: Neuronal primary cilia and chromatin dysregulation - Exploring the missing link in neurodevelopmental disorders using brain organoids
EXPL/MED-OUT/1470/2021
Funders: Fundação para a Ciência e a Tecnologia
2022/03/01 - 2023/03/31
BrainCils: Neuronal primary cilia and chromatin dysregulation - Exploring the missing link in neurodevelopmental disorders using brain organoids
EXPL/MED-OUT/1470/2021
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2021/01/01 - 2023/04/30
Evaluation of TETO-OSKM lentiviral constructs in Dementia models
CSD1010A01#IV1010
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: YouthBio Therapeutics
2021/01/01 - 2023/12/31
Disease modelling of frontotemporal dementia in human brain organoids
PTDC/MEC-NEU/4814/2020
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2021/02/01 - 2024/01/31
Postnatal Reorganization of the cerebellum via Neuron-microglia interaction: IL-4 as a mediator between ADHD and allergies
PTDC/MED-NEU/5993/2020
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular; CNC.IBILI
Funders: Fundação para a Ciência e a Tecnologia
2021/03/01 - 2022/12/31
Does healthy microglia rescue neuroinflammation and synaptic dysfunction in human cerebral organoids with FTD-associated mutations?
EN119
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Takeda Pharmaceuticals Asia Pacific Pte Ltd
2019/01/15 - 2025/01/14
Unraveling miRNA contribution to neuroinflammation and dementia
DL 57/2016/CP1448/CT0023
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2018/07/26 - 2021/07/25
The neuroinflammatory reaction to acute systemic inflammation during delirium and its impact in the cognitive trajectory and progression to dementia: a case-control longitudinal study using imaging and molecular biomarkers
PTDC/MEC-PSQ/32501/2017
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2016/01/01 - 2019/01/14
Understanding the contribution of miRNAs to neuroinflammation in Alzheimer´s disease
SFRH/BPD/108312/2015
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2016/04/01 - 2019/10/01
Social hierarchy and early life adversity: optogenetic modulation of prefrontal cortical circuits and neuroepigenetic regulation
PTDC/NEU-SCC/3247/2014
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2013/03 - 2015/03
Combined therapeutic approach based on miRNA modulation towards glioblastoma multiforme: A novel targeted lipid-based nanosystem for systemic delivery
Provided by PTCRIS: 124488
Funders: Fundação para a Ciência e a Tecnologia, I.P.
2013/03/01 - 2015/08/31
Exploring miRNA contribution to amyloid-b-metabolism: development of a novel lentiviral platform for multiple miRNA expression in Alzheimer´s disease
PTDC/BIM-MEC/0651/2012
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2013/03/02 - 2015/06/01
Combined therapeutic approach based on miRNA modulation towards glioblastoma multiforme: A novel targeted lipid-based nanosystem for systemic delivery
PTDC/DTP-FTO/0265/2012
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2013/01/01 - 2014/12/31
PROJECTO ESTRATÉGICO - LA 1 - 2013-2014 PEst-C/SAU/LA0001/2013
PEst-C/SAU/LA0001/2013
Researcher
CNC.IBILI
Funders: Fundação para a Ciência e a Tecnologia
2009/01/01 - 2013/10/31
INFLAMMATORY MECHANISMS IN NEURODEGENERATION: MIRNAS AS REGULATORS OF THE IMMUNE SYSTEM RESPONSE IN ALZHEIMERS DISEASE
SFRH/BPD/46228/2008
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2007/05/01 - 2010/12/31
Development of novel approaches for anti-tumor therapy based on the S413-PV cell penetrating peptide to improve the intracellular delivery of therapeutic nucleic acids and proteins
PTDC/BIO/65627/2006
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2005/01/01 - 2008/12/31
SILENCIAMENTO DE GENES PRÓ-APOPTÓTICOS PARA O TRATAMENTO DA LESÃO CEREBRAL: DESENVOLV. DE VECTORES DE BASE LIPÍDICA PARA POTENCIAR A ENTREGA DE SIRNA E DE GENES CODIFICADORES DE SIRNA NUM MODELO NEURONAL DE ISQUÉMIA
SFRH/BD/17216/2004
PhD Student Fellow
Universidade de Coimbra; Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
5 19 out of 19 projects
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